Sociodemographic Factors and Clinical Conditions Associated to Hospitalization in Influenza A (H1N1) 2009 Virus Infected Patients in Spain, 2009–2010
Identifieur interne : 000A14 ( Main/Exploration ); précédent : 000A13; suivant : 000A15Sociodemographic Factors and Clinical Conditions Associated to Hospitalization in Influenza A (H1N1) 2009 Virus Infected Patients in Spain, 2009–2010
Auteurs : Fernando González-Candelas [Espagne] ; Jenaro Astray [Espagne] ; Jordi Alonso [Espagne] ; Ady Castro [Espagne] ; Rafael Cant N [Espagne] ; Juan Carlos Galán [Espagne] ; Olatz Garin [Espagne] ; Marc Sáez [Espagne] ; Nuria Soldevila [Espagne] ; Maretva Baricot [Espagne] ; Jesús Castilla [Espagne] ; Pere Godoy [Espagne] ; Miguel Delgado-Rodríguez [Espagne] ; Vicente Martín [Espagne] ; José María Mayoral [Espagne] ; Tomás Pumarola [Espagne] ; José María Quintana [Espagne] ; Sonia Tamames [Espagne] ; Angela Domínguez [Espagne]Source :
- PLoS ONE [ 1932-6203 ] ; 2012.
Abstract
The emergence and pandemic spread of a new strain of influenza A (H1N1) virus in 2009 resulted in a serious alarm in clinical and public health services all over the world. One distinguishing feature of this new influenza pandemic was the different profile of hospitalized patients compared to those from traditional seasonal influenza infections. Our goal was to analyze sociodemographic and clinical factors associated to hospitalization following infection by influenza A(H1N1) virus. We report the results of a Spanish nationwide study with laboratory confirmed infection by the new pandemic virus in a case-control design based on hospitalized patients. The main risk factors for hospitalization of influenza A (H1N1) 2009 were determined to be obesity (BMI≥40, with an odds-ratio [OR] 14.27), hematological neoplasia (OR 10.71), chronic heart disease, COPD (OR 5.16) and neurological disease, among the clinical conditions, whereas low education level and some ethnic backgrounds (Gypsies and Amerinds) were the sociodemographic variables found associated to hospitalization. The presence of any clinical condition of moderate risk almost triples the risk of hospitalization (OR 2.88) and high risk conditions raise this value markedly (OR 6.43). The risk of hospitalization increased proportionally when for two (OR 2.08) or for three or more (OR 4.86) risk factors were simultaneously present in the same patient. These findings should be considered when a new influenza virus appears in the human population.
Url:
DOI: 10.1371/journal.pone.0033139
PubMed: 22412995
PubMed Central: 3296770
Affiliations:
- Espagne
- Catalogne, Communauté de Madrid
- Barcelone, Madrid
- Université Pompeu Fabra, Université de Barcelone
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Cajal, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Galan, Juan Carlos" sort="Galan, Juan Carlos" uniqKey="Galan J" first="Juan Carlos" last="Galán">Juan Carlos Galán</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>CIBER Epidemiología y Salud Pública, Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiología y Salud Pública, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff7"><addr-line>Servicio de Microbiología, Hospital Universitario Ramón y Cajal, Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Microbiología, Hospital Universitario Ramón y Cajal, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Garin, Olatz" sort="Garin, Olatz" uniqKey="Garin O" first="Olatz" last="Garin">Olatz Garin</name><affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>Unitat de Recerca en Serveis Sanitaris, Institut Municipal d'Investigació Mèdica-Institut de Recerca de l'Hospital del Mar, Barcelona, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Unitat de Recerca en Serveis Sanitaris, Institut Municipal d'Investigació Mèdica-Institut de Recerca de l'Hospital del Mar, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>CIBER Epidemiología y Salud Pública, Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiología y Salud Pública, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Saez, Marc" sort="Saez, Marc" uniqKey="Saez M" first="Marc" last="Sáez">Marc Sáez</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>CIBER Epidemiología y Salud Pública, Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiología y Salud Pública, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Departament d'Economia, Universitat de Girona, Girona, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Departament d'Economia, Universitat de Girona, Girona</wicri:regionArea><wicri:noRegion>Girona</wicri:noRegion></affiliation></author><author><name sortKey="Soldevila, Nuria" sort="Soldevila, Nuria" uniqKey="Soldevila N" first="Nuria" last="Soldevila">Nuria Soldevila</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>CIBER Epidemiología y Salud Pública, Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiología y Salud Pública, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Baricot, Maretva" sort="Baricot, Maretva" uniqKey="Baricot M" first="Maretva" last="Baricot">Maretva Baricot</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>CIBER Epidemiología y Salud Pública, Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiología y Salud Pública, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Castilla, Jesus" sort="Castilla, Jesus" uniqKey="Castilla J" first="Jesús" last="Castilla">Jesús Castilla</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>CIBER Epidemiología y Salud Pública, Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiología y Salud Pública, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff9"><addr-line>Instituto de Salud Pública de Navarra, Pamplona, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Instituto de Salud Pública de Navarra, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Godoy, Pere" sort="Godoy, Pere" uniqKey="Godoy P" first="Pere" last="Godoy">Pere Godoy</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>CIBER Epidemiología y Salud Pública, Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiología y Salud Pública, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff10"><addr-line>Departament de Salut, Generalitat de Catalunya, Barcelona, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Departament de Salut, Generalitat de Catalunya, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Delgado Rodriguez, Miguel" sort="Delgado Rodriguez, Miguel" uniqKey="Delgado Rodriguez M" first="Miguel" last="Delgado-Rodríguez">Miguel Delgado-Rodríguez</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>CIBER Epidemiología y Salud Pública, Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiología y Salud Pública, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff11"><addr-line>División de Medicina Preventiva y Salud Pública, Universidad de Jaén, Jaén, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>División de Medicina Preventiva y Salud Pública, Universidad de Jaén, Jaén</wicri:regionArea><wicri:noRegion>Jaén</wicri:noRegion></affiliation></author><author><name sortKey="Martin, Vicente" sort="Martin, Vicente" uniqKey="Martin V" first="Vicente" last="Martín">Vicente Martín</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>CIBER Epidemiología y Salud Pública, Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiología y Salud Pública, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff12"><addr-line>Instituto de Biomedicina, Universidad de León, León, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Instituto de Biomedicina, Universidad de León, León</wicri:regionArea><wicri:noRegion>León</wicri:noRegion></affiliation></author><author><name sortKey="Mayoral, Jose Maria" sort="Mayoral, Jose Maria" uniqKey="Mayoral J" first="José María" last="Mayoral">José María Mayoral</name><affiliation wicri:level="1"><nlm:aff id="aff13"><addr-line>Servicio de Vigilancia de Andalucía, Sevilla, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Vigilancia de Andalucía, Sevilla</wicri:regionArea><wicri:noRegion>Sevilla</wicri:noRegion></affiliation></author><author><name sortKey="Pumarola, Tomas" sort="Pumarola, Tomas" uniqKey="Pumarola T" first="Tomás" last="Pumarola">Tomás Pumarola</name><affiliation wicri:level="3"><nlm:aff id="aff14"><addr-line>Red Española de Investigación en Patologías Infecciosas (REIPI), Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Red Española de Investigación en Patologías Infecciosas (REIPI), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Quintana, Jose Maria" sort="Quintana, Jose Maria" uniqKey="Quintana J" first="José María" last="Quintana">José María Quintana</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>CIBER Epidemiología y Salud Pública, Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiología y Salud Pública, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff15"><addr-line>Fundación Vasca de Innovación e Investigación Sanitarias, Sondika, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Fundación Vasca de Innovación e Investigación Sanitarias, Sondika</wicri:regionArea><wicri:noRegion>Sondika</wicri:noRegion></affiliation></author><author><name sortKey="Tamames, Sonia" sort="Tamames, Sonia" uniqKey="Tamames S" first="Sonia" last="Tamames">Sonia Tamames</name><affiliation wicri:level="1"><nlm:aff id="aff16"><addr-line>Dirección General de Salud Pública, Desarrollo e Innovación, Junta de Castilla y León, Valladolid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Dirección General de Salud Pública, Desarrollo e Innovación, Junta de Castilla y León, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author><author><name sortKey="Dominguez, Angela" sort="Dominguez, Angela" uniqKey="Dominguez A" first="Angela" last="Domínguez">Angela Domínguez</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>CIBER Epidemiología y Salud Pública, Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiología y Salud Pública, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff17"><addr-line>Departament de Salut Pública, Universitat de Barcelona, Barcelona, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Departament de Salut Pública, Universitat de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université de Barcelone</orgName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The emergence and pandemic spread of a new strain of influenza A (H1N1) virus in 2009 resulted in a serious alarm in clinical and public health services all over the world. One distinguishing feature of this new influenza pandemic was the different profile of hospitalized patients compared to those from traditional seasonal influenza infections. Our goal was to analyze sociodemographic and clinical factors associated to hospitalization following infection by influenza A(H1N1) virus. We report the results of a Spanish nationwide study with laboratory confirmed infection by the new pandemic virus in a case-control design based on hospitalized patients. The main risk factors for hospitalization of influenza A (H1N1) 2009 were determined to be obesity (BMI≥40, with an odds-ratio [OR] 14.27), hematological neoplasia (OR 10.71), chronic heart disease, COPD (OR 5.16) and neurological disease, among the clinical conditions, whereas low education level and some ethnic backgrounds (Gypsies and Amerinds) were the sociodemographic variables found associated to hospitalization. The presence of any clinical condition of moderate risk almost triples the risk of hospitalization (OR 2.88) and high risk conditions raise this value markedly (OR 6.43). The risk of hospitalization increased proportionally when for two (OR 2.08) or for three or more (OR 4.86) risk factors were simultaneously present in the same patient. 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uniqKey="Monegal J">JS Monegal</name></author><author><name sortKey="Kolte, I" uniqKey="Kolte I">I Kolte</name></author><author><name sortKey="Verstraeten, T" uniqKey="Verstraeten T">T Verstraeten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Banzhoff, A" uniqKey="Banzhoff A">A Banzhoff</name></author><author><name sortKey="Haertel, S" uniqKey="Haertel S">S Haertel</name></author><author><name sortKey="Praus, M" uniqKey="Praus M">M Praus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ikematsu, H" uniqKey="Ikematsu H">H Ikematsu</name></author><author><name sortKey="Nagai, H" uniqKey="Nagai H">H Nagai</name></author><author><name sortKey="Kawashima, M" uniqKey="Kawashima M">M Kawashima</name></author><author><name sortKey="Kawakami, Y" uniqKey="Kawakami Y">Y Kawakami</name></author><author><name sortKey="Tenjinbaru, K" uniqKey="Tenjinbaru K">K 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Madrid</li></region><settlement><li>Barcelone</li><li>Madrid</li></settlement><orgName><li>Université Pompeu Fabra</li><li>Université de Barcelone</li></orgName></list><tree><country name="Espagne"><noRegion><name sortKey="Gonzalez Candelas, Fernando" sort="Gonzalez Candelas, Fernando" uniqKey="Gonzalez Candelas F" first="Fernando" last="González-Candelas">Fernando González-Candelas</name></noRegion><name sortKey="Alonso, Jordi" sort="Alonso, Jordi" uniqKey="Alonso J" first="Jordi" last="Alonso">Jordi Alonso</name><name sortKey="Alonso, Jordi" sort="Alonso, Jordi" uniqKey="Alonso J" first="Jordi" last="Alonso">Jordi Alonso</name><name sortKey="Alonso, Jordi" sort="Alonso, Jordi" uniqKey="Alonso J" first="Jordi" last="Alonso">Jordi Alonso</name><name sortKey="Astray, Jenaro" sort="Astray, Jenaro" uniqKey="Astray J" first="Jenaro" last="Astray">Jenaro Astray</name><name sortKey="Baricot, Maretva" sort="Baricot, Maretva" uniqKey="Baricot M" first="Maretva" last="Baricot">Maretva 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sort="Saez, Marc" uniqKey="Saez M" first="Marc" last="Sáez">Marc Sáez</name><name sortKey="Saez, Marc" sort="Saez, Marc" uniqKey="Saez M" first="Marc" last="Sáez">Marc Sáez</name><name sortKey="Soldevila, Nuria" sort="Soldevila, Nuria" uniqKey="Soldevila N" first="Nuria" last="Soldevila">Nuria Soldevila</name><name sortKey="Tamames, Sonia" sort="Tamames, Sonia" uniqKey="Tamames S" first="Sonia" last="Tamames">Sonia Tamames</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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